Publication:
Multiscale modeling of human bone

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Authors
Kwon, Y.W.
Clumpner, B.R.
Subjects
Multiscale model
Biomaterial
Bone
Advisors
Date of Issue
2018-04-17
Date
17 April 2018
Publisher
SpringerLink
Language
Abstract
A multiscale modeling technique was developed to predict mechanical properties of human bone, which utilizes the hierarchies of human bone in different length scales from nanoscale to macroscale. Bone has a unique structure displaying high stiffness with minimal weight. This is achieved through a hierarchy of complex geometries composed of three major materials: hydroxyapatite, collagen and water. The identifiable hierarchical structures of bone are hydroxyapatite, tropocollagen, fibril, fiber, lamellar layer, trabecular bone, cancellous bone and cortical bone. A helical spring model was used to represent the stiffness of collagen. A unit cell-based micromechanics model computed both the normal and shear stiffness of fibrils, fibers, and lamellar layers. A laminated composite model was applied to cortical and trabecular bone, while a simplified finite element model for the tetrakaidecahedral shape was used to evaluate cancellous bone. Modeling bone from nanoscale components to macroscale structures allows the influence of each structure to be assessed. It was found that the distribution of hydroxyapatite within the tropocollagen matrix at the fibril level influences the macroscale properties significantly. Additionally, the multiscale analysis model can vary any parameter of any hierarchical level to determine its effect on the bone property. With so little known about the detailed structure of nanoscale and microscale bone, a model encompassing the complete hierarchy of bone can be used to help validate assumptions or hypotheses about those structures.
Type
Article
Description
The article of record as published may be found at http://dx.doi.org/10.1007/s41939-018-0013-0
Series/Report No
Department
Mechanical and Aerospace Engineering (MAE)
Organization
Naval Postgraduate School (U.S.)
Identifiers
NPS Report Number
Sponsors
Funder
Format
11 p.
Citation
Y.W. Kwon, B.R. Clumpner. "Multiscale modeling of human bone." Multiscale and Multidisciplinary Modeling, Experiments and Design; June 2018, Volume 1, Issue 2, pp 133–143.
Distribution Statement
Rights
This publication is a work of the U.S. Government as defined in Title 17, United States Code, Section 101. Copyright protection is not available for this work in the United States.
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