Stochastic models for cell signaling and toxic effects on cells
Loading...
Authors
Gaver, Donald Paul
Jacobs, Patricia A.
Carpenter, Robert L.
Narayanan, Tandore K.
Subjects
NA
Advisors
Date of Issue
1994-12
Date
1994-12
Publisher
Monterey, California. Naval Postgraduate School
Language
en_US
Abstract
This paper presents generic models for the effect of a chemical toxin on cells forming the tissue of an organ. The models are illustrative, not specific to organ or toxin. Interactive response of within-tissue toxin and cells is modeled: cell capability to modify (metabolize or bind) toxin is represented, as is the alteration of that capability by toxin presence. Both processes are represented in the context of simple versions of the cell cyde. Toxin-cell interaction is explicitly represented in terms of inter-cell chemical signaling that encourages replacement or repair of cells. The impact of cell death by apoptosis and necrosis is represented in terms of within-tissue toxin concentration. The model is explicitly stochastic, representing inter-cell and toxin input and within-organ concentration in terms of diffusion approximations. Explicit mathematical discussion is given of dose-response function behavior at low doses
Type
Technical Report
Description
Series/Report No
Department
Operations Research
Identifiers
NPS Report Number
NPS-OR-94-016
Sponsors
Naval Medical Research Institute/Toxicology Detachment Wright-Patterson Air Force Base, Ohio
Funder
Naval Medical Research Institute/Toxicology Detachment Wright-Patterson Air Force Base, Ohio
Format
Citation
Distribution Statement
Rights
This publication is a work of the U.S. Government as defined in Title 17, United States Code, Section 101. Copyright protection is not available for this work in the United States.