Modeling and statistical analysis of Medaka bioassay data
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Authors
Gaver, Donald Paul
Jacobs, Patricia A.
Subjects
Binomial Distribution; censored data; generalized linear model; bootstrap
Advisors
Date of Issue
1992-05
Date
1992-05
Publisher
Monterey, California. Naval Postgraduate School
Language
en_US
Abstract
A histopathologic examination of tissues from Oryzias laptipes (Japanese medaka fish) was performed to evaluate the carcinogenic potential of tricholoroethylene (TCE) in groundwater. The data were reported by Experimental Pathology Laboratories, Inc., in a report dated Jan. 19, 1990, submitted to the Army Biomedical Research and Development Laboratory, Ft. Detrick, MD. This paper provides a brief statistical analysis of some aspects of those data. The analysis does not reveal a strong positive relationship between TCE concentration over the range considered and probability (risk or hazard) of incurring at least one end point manifestation (here cystic degeneration or liver neoplasm) in a fish. Uncertainties in the point estimates are assessed by bootstrapping. Both non-parametric (weak statistical assumptions) and parametric (stronger statistical assumptions) analyses give similar inconclusive dose- response indications. A brief discussion is included of a biologically-based mathematical model that is likely to form an appropriate basis for more sophisticated data analysis. One contribution of this paper is to discuss and illustrate techniques for quantitative analysis of other similar data. The methods can also be used to assist in choosing an experimental design. Binomial Distribution; Censored data; Generalized linear model; Bootstrap
Type
Technical Report
Description
Series/Report No
Department
Operations Research
Organization
Naval Postgraduate School (U.S.)
Identifiers
NPS Report Number
NPS-OR-92-012
Sponsors
Prepared for: Army Biomedical Research and Development Laboratory, Ft. Detrick MD
Funding
Prepared for: Army Biomedical Research and Development Laboratory, Ft. Detrick MD
Format
Citation
Distribution Statement
Rights
This publication is a work of the U.S. Government as defined in Title 17, United States Code, Section 101. Copyright protection is not available for this work in the United States.