A study of the synthesis of 2-trifluoromethyl pyrimidines.
dc.contributor.advisor | McFarlin, George H. | |
dc.contributor.author | King, John A. | |
dc.date | 1961 | |
dc.date.accessioned | 2012-08-29T23:36:15Z | |
dc.date.available | 2012-08-29T23:36:15Z | |
dc.date.issued | 1961 | |
dc.identifier.uri | http://hdl.handle.net/10945/13189 | |
dc.description.abstract | iPhenylbutanedione-1,3 and 2,4-pentanedione were reacted with trifluoroacetamidine in the presence of sodium ethoxide. A crystalline product melting at 38.4°C was recovered from the reaction of 2 ,4-pentanedione and trifluoroacetamidine and tentatively identified by its infrared spectra as 2-trifluoromethyl-4-,6-dimethylpyrimidine<> The reaction of trifluoroacetamidine and phenylbutanedione-1, 3 in the presence of sodium ethoxide yielded a white crystalline product melting at 90.3°C which was also tentatively identified as the 2-trifluoromethyl-4-methyl- 6-phenylpyrimidine. The amidine of trifluoroacetic acid reacted in a manner described for the reaction of an amidine with a beta-diketone. Yields obtained (19-34%) were within the limits reported for many other pyrimidine syntheses, influenced in part by the instability of trifluoroacetamidine. | |
dc.description.uri | http://archive.org/details/astudyofsynthesi1094513189 | |
dc.language.iso | en_US | |
dc.publisher | Monterey, California: U.S. Naval Postgraduate School | en_US |
dc.rights | This publication is a work of the U.S. Government as defined in Title 17, United States Code, Section 101. Copyright protection is not available for this work in the United States. | |
dc.subject.lcsh | Chemistry | en_US |
dc.title | A study of the synthesis of 2-trifluoromethyl pyrimidines. | en_US |
dc.type | Thesis | en_US |
dc.contributor.corporate | Naval Postgraduate School (U.S.) | |
dc.contributor.department | Metallurgy and Chemistry | |
dc.description.service | Captain, United States Air Force | |
etd.thesisdegree.name | M.S. | en_US |
etd.thesisdegree.level | Masters | en_US |
etd.thesisdegree.grantor | Naval Postgraduate School | en_US |
dc.description.distributionstatement | Approved for public release; distribution is unlimited. |
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