Show simple item record

dc.contributor.advisorMcFarlin, George H.
dc.contributor.authorKing, John A.
dc.date1961
dc.date.accessioned2012-08-29T23:36:15Z
dc.date.available2012-08-29T23:36:15Z
dc.date.issued1961
dc.identifier.urihttp://hdl.handle.net/10945/13189
dc.descriptionApproved for public release; distribution is unlimited
dc.description.abstractiPhenylbutanedione-1,3 and 2,4-pentanedione were reacted with trifluoroacetamidine in the presence of sodium ethoxide. A crystalline product melting at 38.4°C was recovered from the reaction of 2 ,4-pentanedione and trifluoroacetamidine and tentatively identified by its infrared spectra as 2-trifluoromethyl-4-,6-dimethylpyrimidine<> The reaction of trifluoroacetamidine and phenylbutanedione-1, 3 in the presence of sodium ethoxide yielded a white crystalline product melting at 90.3°C which was also tentatively identified as the 2-trifluoromethyl-4-methyl- 6-phenylpyrimidine. The amidine of trifluoroacetic acid reacted in a manner described for the reaction of an amidine with a beta-diketone. Yields obtained (19-34%) were within the limits reported for many other pyrimidine syntheses, influenced in part by the instability of trifluoroacetamidine.
dc.description.urihttp://www.archive.org/details/studyofsynthesis00king
dc.language.isoen_US
dc.publisherMonterey, California: U.S. Naval Postgraduate Schoolen_US
dc.rightsThis publication is a work of the U.S. Government as defined in Title 17, United States Code, Section 101. Copyright protection is not available for this work in the United States.
dc.subject.lcshChemistryen_US
dc.titleA study of the synthesis of 2-trifluoromethyl pyrimidines.en_US
dc.typeThesisen_US
dc.contributor.corporateNaval Postgraduate School (U.S.)
dc.contributor.departmentMetallurgy and Chemistry
dc.description.serviceCaptain, United States Air Force
etd.thesisdegree.nameM.S.en_US
etd.thesisdegree.levelMastersen_US
etd.thesisdegree.grantorNaval Postgraduate Schoolen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

  • Thesis and Dissertation Collection
    Includes the entire collection of publicly accessible NPS Theses, Dissertations and other degree earning works. Other collections here are mapped from this one.

Show simple item record