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dc.contributor.advisorMcFarlin, George H.
dc.contributor.authorKing, John A.
dc.date1961
dc.date.accessioned2012-08-29T23:36:15Z
dc.date.available2012-08-29T23:36:15Z
dc.date.issued1961
dc.identifier.urihttp://hdl.handle.net/10945/13189
dc.descriptionApproved for public release; distribution is unlimited
dc.description.abstractiPhenylbutanedione-1,3 and 2,4-pentanedione were reacted with trifluoroacetamidine in the presence of sodium ethoxide. A crystalline product melting at 38.4°C was recovered from the reaction of 2 ,4-pentanedione and trifluoroacetamidine and tentatively identified by its infrared spectra as 2-trifluoromethyl-4-,6-dimethylpyrimidine<> The reaction of trifluoroacetamidine and phenylbutanedione-1, 3 in the presence of sodium ethoxide yielded a white crystalline product melting at 90.3°C which was also tentatively identified as the 2-trifluoromethyl-4-methyl- 6-phenylpyrimidine. The amidine of trifluoroacetic acid reacted in a manner described for the reaction of an amidine with a beta-diketone. Yields obtained (19-34%) were within the limits reported for many other pyrimidine syntheses, influenced in part by the instability of trifluoroacetamidine.
dc.description.urihttp://www.archive.org/details/studyofsynthesis00king
dc.language.isoen_US
dc.publisherMonterey, California: U.S. Naval Postgraduate Schoolen_US
dc.rightsThis publication is a work of the U.S. Government as defined in Title 17, United States Code, Section 101. Copyright protection is not available for this work in the United States.
dc.subject.lcshChemistryen_US
dc.titleA study of the synthesis of 2-trifluoromethyl pyrimidines.en_US
dc.typeThesisen_US
dc.contributor.corporateNaval Postgraduate School (U.S.)
dc.contributor.departmentMetallurgy and Chemistry
dc.description.serviceCaptain, United States Air Force
etd.thesisdegree.nameM.S.en_US
etd.thesisdegree.levelMastersen_US
etd.thesisdegree.grantorNaval Postgraduate Schoolen_US


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