An exploratory stochastic model for toxic effects on cells
Gaver, Donald Paul
Jacobs, Patricia A.
MetadataShow full item record
A multivariate dynamic Markov model is formulated to describe the possible effect of a generic chemical toxin on a generic cell population in an organ. Asymptotic methods (large cell population) are used to show that numbers and toxin may be jointly Gaussian/normally distributed; the joint stochastic process is approximately Ornstein-Uhlenbeck. Application to dose-response, and hence risk analysis, is briefly discussed.
RightsThis publication is a work of the U.S. Government as defined in Title 17, United States Code, Section 101. Copyright protection is not available for this work in the United States.
NPS Report NumberNPS-OR-93-014