Publication:
An exploratory stochastic model for toxic effects on cells

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Authors
Gaver, Donald Paul
Jacobs, Patricia A.
Carpenter, R.L.
Subjects
Biological Cells
Toxic Chemicals
Advisors
Date of Issue
1993-09
Date
1993-09
Publisher
Monterey, California. Naval Postgraduate School
Language
en_US
Abstract
A multivariate dynamic Markov model is formulated to describe the possible effect of a generic chemical toxin on a generic cell population in an organ. Asymptotic methods (large cell population) are used to show that numbers and toxin may be jointly Gaussian/normally distributed; the joint stochastic process is approximately Ornstein-Uhlenbeck. Application to dose-response, and hence risk analysis, is briefly discussed.
Type
Technical Report
Description
Series/Report No
Department
Operations Research
Other Units
Naval Postgraduate School (U.S.)
Identifiers
NPS Report Number
NPS-OR-93-014
Sponsors
Naval Medical Research Institute / Toxicology Detachment, Wright-Patterson Air Force Base, Ohio
Funder
RN2GA, RDFDG
Format
Citation
Distribution Statement
Approved for public release; distribution is unlimited.
Rights
This publication is a work of the U.S. Government as defined in Title 17, United States Code, Section 101. Copyright protection is not available for this work in the United States.
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