Statistical properties and inference of the antimicrobial MIC test
Annis, David H.
Craig, Bruce A.
MetadataShow full item record
A common method for measuring the drug-speci c minimum inhibitory concentration (MIC) of an antibacterial agent is via a two-fold broth dilution test known as the MIC test. Because this procedure implicitly rounds data upward, inference based on unadjusted measurements is biased and overestimates bacterial resistance to a drug. We detail this test procedure and its associated bias, which, in many cases, has an expected value of approximately 0.5 on the log2 scale. In addition, new bias-corrected estimates of resistance are proposed. A numeric example is used to illustrate the extent to which the traditional resistance estimate can overestimate the true proportion of resistant strains, a phenomenon which is remedied by using the proposed estimates.
Showing items related by title, author, creator and subject.
Braendle, J. E.; Ringelberg, J. M. (Webb Institute of Naval Architecture, 1967-05-30);A symmetrical hull catamaran with dimensions 1n line with current proposed submarine rescue vessels was designed and tested at several hull spacings in order to determine the effect of separation on resistance. A single ...
Effects of precipitate size and surface normal orientation on micro-identification and compressive fatigue of NiTi shape memory alloys Juntunen, Kevin K. (2001);This work seeks to determine the evolution of the indentation and fatigue response of heat-treated Nickel-Titanium shape memory alloys over a range of precipitate sizes and surface normal orientations. Various tests were ...
Effect of annealing on the passive film stability and corrosion resistance of new families of iron-based amorphous metals Omlor, Timothy (Monterey, California. Naval Postgraduate School, 2011-06);Iron-based amorphous metals have incredible strength and hardness, and with the addition of alloying constituents, can also be formulated to have exceptional corrosion resistance. Compositions of several iron-based amorphous ...