Surviving the 'storm': expanding public health's capabilities in response to the increasing threats posed by novel, pandemic strain viruses

Abstract

The recent emergence of two separate outbreaks of two new viruses has generated renewed interest in the threat of pandemics. For a significant portion of the total fatalities associated with these infections the cause of death was due to an over-reaction of an infected body’s immune system. This research explores possible pharmaceutical interventions that would help expand the list of options public health could employ in a response. For inclusion in state stockpiles, medications must meet three specific criteria: medical efficacy, cost, and logistical considerations. We identified four medications that could be employed (three statins - atorvastatin, simvastatin, and gemfibrozil and an antiviral – ribavirin) and present options for their inclusion into state stockpiles. Through this research we have attempted to open a dialogue with other federal and state planners as they wrestle with the same challenges within their home agencies.